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Alexander Wlodawer

Senior Investigator
Macromolecular Crystallography Laboratory, CCR
National Cancer Institute
United States of America

Biography

Dr. Alexander Wlodawer received his Ph.D. from the University of California, Los Angeles, in 1974. Having completed his postdoctoral training at Stanford University, he joined the National Bureau of Standards in 1976, then moved to the ABL-Basic Research Program at the NCI-FCRDC in 1987. From October 1998 to March 1999, he was on sabbatical as an elected Visiting Fellow of Sidney Sussex College, University of Cambridge. In 1999, Dr. Wlodawer was appointed Chief of the Macromolecular Crystallography Laboratory, CCR, NCI. Dr. Wlodawer is an Adjunct Professor in the George Washington University Institute of Biomedical Sciences and Doctor Honoris Causa of the Technical University of Lodz, Poland. He was elected Foreign Member of the Polish Academy of Sciences in 2005, is a recipient of the 2006 NCI Mentor of Merit Award, and was awarded the Heyrovsky Honorary Medal by the Czech Academy of Sciences in 2008. He is a member of the American Crystallographic Association and was elected ACA Fellow in 2013. He has served as an Editor of the FEBS Journal since 2007, as an Associate Editor of FEBS OpenBio since 2011, and as Academic Editor of PLoS ONE since 2013. He also serves on the editorial board of Acta Biochimica Polonica.

Research Interest

1) Protein crystallography, 2) Expression and purification of proteins, 3) Development of crystallographic techniques, 4) Analysis of the quality of crystal structures, 5) Proteolytic enzymes, 6) Viral proteins, 7) The relationship between protein structure and function by high-resolution X-ray diffraction, 8) Immunology, 9) Structural Biology, 10) Virology

Publications

  • Crystal structure of a retroviral protease proves relationship to aspartic protease family.

  • High-resolution structure of the catalytic domain of avian sarcoma virus integrase.

  • Crystal structure of interleukin 8: symbiosis of NMR and crystallography.

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