Andre Nussenzweig
Chief
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Dr. Nussenzweig received his Ph.D. in Physics from Yale University in 1989. He completed his postdoctoral training in atomic physics in Paris with Dr. Serge Haroche, who was awarded the Nobel prize in Physics in 2012. Subsequently, Dr. Nussenzweig became a Research Fellow at Memorial Sloan-Kettering Cancer Center prior to joining the Experimental Immunology Branch as a tenure track investigator in 1998. Dr. Nussenzweig received tenure at NIH in 2003. In 2011, Dr. Nussenzweig established a new department at NCI called the Laboratory of Genome Integrity. Dr. Nussenzweig is an elected member of the European Molecular Biology Organization and a National Institutes of Health Distinguished Investigator.
Research Interest
1) genomic Instability, 2) DNA damage/repair, 3) breast/ovarian cancers, 4) recombination/replication, 5) chromosomal translocations, 6) adult/pediatric leukemias
Publications
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Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, Canela A, Onozawa M, Lee JE, Callen E, Gutierrez-Martinez P, Chen HT. DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature. 2014 Oct 2;514(7520):107.
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Chaudhuri AR, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S. Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. 2016 Jul 21;535(7612):382.
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Canela A, Maman Y, Jung S, Wong N, Callen E, Day A, Kieffer-Kwon KR, Pekowska A, Zhang H, Rao SS, Huang SC. Genome Organization Drives Chromosome Fragility. Cell. 2017 Jul 27;170(3):507-21.
