Avinash Bhandoola
Senior Investigator
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Avinash Bhandoola received a Ph.D. from the University of Pennsylvania in 1994, and did a postdoctoral fellowship with Dr. Alfred Singer at NCI focused on T cell development. He joined the faculty of the University of Pennsylvania in 2001, received tenure in 2007, and was promoted to full professor in 2012. He subsequently joined the Laboratory of Genome Integrity in 2014.
Research Interest
transcription factors that establish and maintain T cell identity, T cell regeneration and bone marrow transplantation, thymic epithelial cells
Publications
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Yang Q, Monticelli LA, Saenz SA, Chi AW, Sonnenberg GF, Tang J, De Obaldia ME, Bailis W, Bryson JL, Toscano K, Huang J. T cell factor 1 is required for group 2 innate lymphoid cell generation. Immunity. 2013 Apr 18;38(4):694-704.
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De Obaldia ME, Bell JJ, Wang X, Harly C, Yashiro-Ohtani Y, DeLong JH, Zlotoff DA, Pear WS, Bhandoola A. T cell development requires constraint of the myeloid regulator C/EBP-[alpha] by the Notch target and transcriptional repressor Hes1. Nature immunology. 2013 Dec 1;14(12):1277-84.
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Zhang SL, Wang X, Manna S, Zlotoff DA, Bryson JL, Blazar BR, Bhandoola A. Chemokine treatment rescues profound T-lineage progenitor homing defect after bone marrow transplant conditioning in mice. Blood. 2014 Jul 10;124(2):296-304.
