Barbara K. Felber
Senior Investigator
Vaccine Branch, Human Retrovirus Pathogenesis Section, CCR
National Cancer Institute
United States of America
Biography
Dr. Barbara K. Felber received her Ph.D. in molecular biology from the University of Bern, Switzerland. After carrying out postdoctoral studies in the Laboratory of Biochemistry, NCI Bethesda, she joined the Molecular Mechanisms of Carcinogenesis Laboratory, the NCI contract Basic Research Program, in 1985. In 1990, Dr. Felber established the Human Retrovirus Pathogenesis Group. In 1998, Dr. Felber received her tenure appointment and, in 1999, she joined the Center for Cancer Research, NCI. Her work focuses on the posttranscriptional mechanisms of gene regulation, use of cytokines in cancer and AIDS,and the development of DNA-based HIV vaccines.
Research Interest
1) HIV 2) gene expression 3) mRNA 4) HIV pathogenesis 5) retrovirus, protein, gene regulation, immunology 6) DNA vaccine 7) use of DNA-based vaccine strategies both as preventive and immunotherapeutic approaches to control HIV 8) develop DNA-based strategies for improved vaccination against HIV/SIV
Publications
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The p40 subunit of interleukin (IL)-12 promotes stabilization and export of the p35 subunit: implications for improved IL-12 cytokine production.
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Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization.
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TAP, the human homolog of Mex67p, mediates CTE-dependent RNA export from the nucleus.
