Oncology Experts

Christine M. Heske

Assistant Clinical Investigator
Pediatric Oncology Branch. CCR
National Cancer Institute
United States of America


Dr. Heske is a physician scientist with a research focus on preclinical and clinical investigation of novel therapeutic agents in pediatric sarcomas. Specifically, she seeks to identify and evaluate new therapeutic targets for Ewing sarcoma, rhabdomyosarcoma and osteosarcoma. In addition, her efforts include understanding the mechanisms behind therapeutic resistance in pediatric sarcomas and developing strategies to overcome such resistance. After completing her undergraduate work at Harvard University, Dr. Heske received her M.D. from The George Washington University School of Medicine and Health Sciences in 2008. She completed her pediatric internship and residency at Brown University/Hasbro Children's Hospital, followed by her fellowship training at the combined National Cancer Institute-Johns Hopkins University Pediatric Hematology and Oncology program, where she served as Chief Fellow. Dr. Heske is board certified in General Pediatrics (2011) and Pediatric Hematology/Oncology (2015) and is currently an Assistant Clinical Investigator in the POB.

Research Interest

1) Pediatric sarcoma 2) Molecular oncology 3) Experimental therapeutics 4) Translational and clinical research in the area of pediatric sarcomas


  • IGF-1R inhibition activates a YES/SFK Bypass Resistance Pathway: Rational Basis for Co-Targeting IGF-1R and Yes/SFK Kinase in Rhabdomyosarcoma

  • STA-8666, a novel HSP90 inhibitor/SN-38 drug conjugate, causes complete tumor regression in preclinical mouse models of pediatric sarcoma

  • The role of PDGFR-β activation in acquired resistance to IGF-1R blockade in preclinical models of rhabdomyosarcoma

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