Chuan Wu
Investigator
Experimental Immunology Branch, CCR
National Cancer Institute
United States of America
Biography
Dr. Chuan Wu is affiliated to the Department of Experimental Immunology Branch, CCR, National Cancer Institute. Dr. Chuan Wu is currently providing services as Investigator. Dr. Chuan Wu has authored and co-authored multiple peer-reviewed scientific papers and presented works at many national and International conferences. Dr. Chuan Wu contributions have acclaimed recognition from honourable subject experts around the world. Dr. Chuan Wu is actively associated with different societies and academies. Dr. Chuan Wu academic career is decorated with several reputed awards and funding. Dr. Chuan Wu research interests include 1) T cell differentiation and function 2) inflammation 3) neuron-immune interaction 4) mucosal immune response 5) Cytokine regulation of intestinal peristalsis 6) Reciprocal regulation of colonic Treg cell (cTreg) and enteric neuron 7) Human ENS lineages for cell therapy and drug discovery in humanized colitis model.. Dr. Wu completed his M.D. studies in China at Shanghai Jiaotong University School of Medicine, and then studied immunology and matrix biology as a graduate student at Muenster University, Germany. His main focus was T cell migration during the central nervous system (CNS) inflammation. He joined Dr. Vijay Kuchroo’s lab in Brigham and Women’s Hospital, Harvard Medical School as a postdoctoral fellow where he studied the molecular regulation of T cell differentiation during inflammation and autoimmunity. In 2017, Dr. Wu started a position as an NIH Stadtman Tenure-Track Investigator at the Experimental Immunology Branch where he studies the cellular and molecular mechanisms of neuro-immune interactions.
Research Interest
1) T cell differentiation and function 2) inflammation 3) neuron-immune interaction 4) mucosal immune response 5) Cytokine regulation of intestinal peristalsis 6) Reciprocal regulation of colonic Treg cell (cTreg) and enteric neuron 7) Human ENS lineages for cell therapy and drug discovery in humanized colitis model.
Publications
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Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, and Kuchroo VK. Proc Natl Acad Sci U S A. 110(19): 7802-7, 2013. [ Journal Article ]
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Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Wu C, Thalhamer T, Franca RF, Xiao S, Wang C, Hotta C, Zhu C, Hirashima M, Anderson AC, and Kuchroo VK. Immunity. 41(2): 270-82, 2014. [ Journal Article ]
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The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program. Wu C*, Chen Z, Dardalhon V, Xiao S, Thalhamer T, Liao M, Madi A, Franca RF, Han T, Oukka M, and Kuchroo VK. *Corresponding author. Nature Immunology. 18(3): 344-53, 2017. [ Journal Article ]