Daniel C. Edelman
Facility Head
Center for Cancer Research
National Cancer Institute
United States of America
Biography
The CMPC Mission By developing and implementing state of the art genomic technologies, the Clinical Molecular Profiling Core maximizes the clinical benefits and biological insights derived from the analysis of biospecimens obtained from National Cancer Institutes clinical trials. Core Activities: Research & Clinical (CLIA) The Clinical Molecular Profiling Core (CMPC) was established in 2006 under the auspices of the Center for Cancer Research, National Cancer Institute. The vision was to create a robust and scientifically advanced laboratory program that would bring the tools of genome technology to bear on NCI intramural clinical trials. It has become increasingly recognized in this new era of targeted therapies that critical aspects of tumor biology can be elucidated by analysis of the cancer genome. Clinical trial outcomes could be better characterized with analysis of cancer genomes with respect to properties such as copy number aberrations, epigenomics, mRNA, and micro-RNA profiles. Importantly, these data also can drive discovery of new tumor subsets and therapeutically relevant genomic features which can lead to personalized cancer treatments. The CMPC creates the opportunity to make the necessary molecular analyses available to any NCI clinical investigator. Being a CLIA compliant laboratory magnifies our impact which allows us to raise the bar on personalized cancer medicine. In order to keep CMPC technologies at the state-of-the-art, the Core includes a technology research and development component in its mission to innovate and develop new cutting edge applications that would widen the applicability of genome technologies to clinically accessible samples.
Research Interest
genomic technologies, biospecimen analysis
Publications
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Waterfall JJ, Arons E, Walker RL, Pineda M, Roth L, Killian JK, Abaan OD, Davis SR, Kreitman RJ, Meltzer PS. High prevalence of MAP2K1 mutations in variant and IGHV4-34-expressing hairy-cell leukemias. Nature genetics. 2014 Jan 1;46(1):8-10.
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Ellis RJ, Wang Y, Stevenson HS, Boufraqech M, Patel D, Nilubol N, Davis S, Edelman DC, Merino MJ, He M, Zhang L. Genome-wide methylation patterns in papillary thyroid cancer are distinct based on histological subtype and tumor genotype. The Journal of Clinical Endocrinology & Metabolism. 2014 Feb 1;99(2):E329-37.
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Petrini I, Meltzer PS, Kim IK, Lucchi M, Park KS, Fontanini G, Gao J, Zucali PA, Calabrese F, Favaretto A, Rea F. A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors. Nature genetics. 2014 Aug 1;46(8):844-9.
