David A. Davis
Staff Scientist
HIV and AIDS Malignancy Branch, CCR
National Cancer Institute
United States of America
Biography
David A. Davis is a staff Scientist of HIV and AIDS Malignancy Branch at Centre for Cancer Research of National Cancer Institute,USA. He did Masters of Science, Biochemistry-University of Vermont 1987 PhD, Biochemistry-Purdue University 1992 PostDoc 1992-1995, NHLBI, 1996-present - NIH Staff Scientist. As a staff scientist in the Yarchoan lab, Dr. Davis mentors postdoctoral fellows as well as junior scientists in the area of viral oncology. The laboratory has a translational research focus that allows for cross-talk between the clinic and lab aiding in the development of new antiviral and anticancer therapies.
Research Interest
The role of hypoxia and hypoxia response elements in human herpesvirus 8 (also known as KSHV) activation, the role of the HIV-1 protease in the HIV-1 viral life cycle, protease inhibitor/drug development, protein biochemistry, enzymology, oxidative stress and RP-HPLC/mass spectrometry. Current projects involve understanding the mechanism by which oncogenic viruses modulate the immune molecules of infected cells and the discovery and development of drugs to thwart these effects.
Publications
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Thioltransferase (glutaredoxin) is detected within HIV-1 and can regulate the activity of glutathionylated HIV-1 protease in vitro.
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Reversible oxidative modification as a mechanism for regulating retroviral protease dimerization and activation.
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Activation of virus uptake through induction of macropinocytosis with a novel polymerizing peptide.
