Dennis D. Hickstein
Experimental Transplantation and Immunology Branch
National Cancer Institute
United States of America
Dr. Hickstein is a Senior Investigator in Experimental Transplantation and Immunology Branch of CCR trained in hematology and hematopoietic stem cell transplantation at the University of Washington School of Medicine and the Fred Hutchinson Cancer Research center. He was recruited to the NCI in 2000 to transplant newly identifed primary immunodeficiency diseases.Dr. Hickstein’s laboratory is developing new approaches to the treatment of the primary immunodeficiency diseases GATA2 deficiency, DOCK8 deficiency, and leukocyte adhesion deficiency type 1 (LAD-1). The current approach uses allogeneic hematopoietic stem cell transplant and autologous hematopoietic stem cell gene therapy. Studies are carried out in animal models of disease and in human clinical trials.
1) Bone marrow transplant 2) primary immunodeficiency diseases 3) gene therapy 4) zebrafish 5) Cancer Biology, 6) Genetics and Genomics, 7) Stem Cell Biology
brca2 and tp53 collaborate in tumorigenesis in zebrafish.
Nonmyeloablative Allogeneic Hematopoietic Stem-Cell Transplantation for GATA2 Deficiency.
Matched related and unrelated donor hematopoietic stem cell transplantation for DOCK deficiency.