Donald P. Bottaro
Staff Scientist Facility Head
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Dr. Bottaro received his B.A. from The University of Chicago and Ph.D. in cellular and molecular biology from Boston University. For his doctoral research he was named Young Investigator of the Year by the American Microcirculatory Society in 1986. He trained as a postdoctoral fellow at Harvard Medical School before joining the NCI's Laboratory of Cellular and Molecular Biology in 1987, where he helped identify keratinocyte growth factor (KGF), hepatocyte growth factor (HGF) and their respective cell surface receptors. In 2003, Dr. Bottaro joined the NCI's Urologic Oncology Branch, where he continues to study growth factor signaling pathways and their subversion in cancer.
Research Interest
regulation of epithelial cell growth and motility, cellular and molecular oncogenesis, growth factor inhibitors, biomarker development
Publications
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Peruzzi B, Athauda G, Bottaro DP. The von Hippel–Lindau tumor suppressor gene product represses oncogenic β-catenin signaling in renal carcinoma cells. Proceedings of the National Academy of Sciences. 2006 Sep 26;103(39):14531-6.
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Bottaro DP, Liotta LA. Cancer: out of air is not out of action. Nature. 2003 Jun 5;423(6940):593-5.
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Bottaro DP, Rubin JS. Identification of the Hepatocyte Growth Factor Receptor as the c-met Porto-Oncogene Product. Science. 1991 Feb 15;251(4995):802.
