Molecular Biology
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Eric O. Freed

Program Director
Center for Cancer Research
National Cancer Institute
United States of America

Eric O. Freed

Biography

Dr. Eric Freed received his Ph.D. in 1990 in the laboratories of Drs. Rex Risser and Howard Temin at the University of Wisconsin-Madison and did postdoctoral work with Dr. Temin at UW-Madison in 1991. His work in Madison focused on the function of the murine leukemia virus and HIV envelope glycoproteins in membrane fusion and virus entry. He joined the Laboratory of Molecular Microbiology at the National Institute of Allergy and Infectious Diseases (LMM/NIAID) in 1992, where he worked with Dr. Malcolm Martin on a variety of topics relating to virus assembly and entry/post-entry events in the HIV replication cycle. In 1997 he was appointed as a Tenure-Track Investigator in LMM/NIAID, and he was promoted to a tenured Senior Investigator position in 2002. In 2003 Dr. Freed joined the HIV Drug Resistance Program (HIV DRP, renamed as the HIV Dynamics and Replication Program in 2015). He was an Organizer of the 2004 Cold Spring Harbor Meeting on Retroviruses, 2006 ASCB Cell Biology of Retroviruses Conference, 2012 Keystone Conference "Frontiers in HIV Pathogenesis, Therapy and Eradication," 2014 Keystone Conference "Viral Entry, Assembly, Exit and Spread," and Viruses 2016 Conference "At the Forefront of Virus–Host Interactions." In 2009 he was appointed as the first Editor-in-Chief of Viruses; he also currently serves on the Editorial Boards of a number of journals, including Journal of Virology, Retrovirology, Frontiers in Virology, and Journal of Molecular Biology. He was selected as an NCI Mentor of Merit in 2010 for excellence in mentoring and guiding the careers of trainees in cancer research, and in 2011 he was appointed to the NCI Senior Biomedical Research Service. In 2014 Dr. Freed was appointed as the Deputy Director of the HIV DRP and received the 2014 Outstanding Science Alumni Award from Penn State University. He became the Director of the HIV DRP in 2015. In 2016 Dr. Freed received the NCI Research Highlights Award and served on the Scientific Committee of the International Retroviral Nucleocapsid and Assembly Symposium. He is currently serving as Chair of the Collaboratory Advisory Panel of the CCR Center for Molecular Microscopy and Co-Chair of the NIH Virology Interest Group and the Annual Norman P. Salzman Memorial Symposium in Virology. He is also a member of the NIH AIDS Discovery and Development of Therapeutics (ADDT) study section and currently serves as ADDT Chair. Dr. Freed is the Organizer of the Viruses 2018 Conference "Breakthroughs in Virus Biology" and is serving on the Organizing Committee of the 2018 Annual Meeting of the American Society for Virology. He is a Co-Director of the University of Maryland Virology Program and an Adjunct Professor in the Department of Cell Biology and Molecular Genetics at the University of Maryland, College Park.

Research Interest

HIV pathogenesis, virus assembly, retroviruses, virology, cell biology, structural biology

Publications

  • Joshi A, Garg H, Nagashima K, Bonifacino JS, Freed EO. GGA and Arf proteins modulate retrovirus assembly and release. Molecular cell. 2008 Apr 25;30(2):227-38.

  • Waki K, Durell SR, Soheilian F, Nagashima K, Butler SL, Freed EO. Structural and functional insights into the HIV-1 maturation inhibitor binding pocket. PLoS pathogens. 2012 Nov 8;8(11):e1002997.

  • Tedbury PR, Novikova M, Ablan SD, Freed EO. Biochemical evidence of a role for matrix trimerization in HIV-1 envelope glycoprotein incorporation. Proceedings of the National Academy of Sciences. 2016 Jan 12;113(2):E182-90.

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