Frances T. Hakim
Associate Scientist
Experimental Transplantation and Immunology Branch, CCR
National Cancer Institute
United States of America
Biography
Fran Hakim has spent most of her research career at NIH. She completed her doctoral research analyzing a murine inflammatory arthritis model under Joost Oppenheim and her postdoctoral work on murine GVHD models under Gene Shearer. Joining the laboratory of Ron Gress, she focused on immune reconstitution of T and NK cells in the clinical transplant setting. Since 2005 she has headed a transplantation immunology research core facility supporting the clinical protocols of Experimental Transplantation and Immunology Branch, including novel trials on IL-7 therapy, T cell immunotherapy, and autologous transplantation for systemic lupus. Her primary research interests focus on immune reconstitution and chronic graft versus host disease.
Research Interest
1) Immune reconstitution, 2) Chronic graft versus host disease (cGVHD), 3) Clinical Research, 4) Immunology
Publications
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T cells expressing an anti-B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma.
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Upregulation of IFN-Inducible and Damage-Response Pathways in Chronic Graft-versus-Host Disease.
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Comparative analysis of FoxP3(+) regulatory T cells in the target tissues and blood in chronic graft versus host disease.
