Gordon L. Hager
Senior Investigator
Laboratory of Receptor Biology and Gene Expression, CCR
National Cancer Institute
United States of America
Biography
Dr. Hager received his Ph.D. in genetics at the University of Washington in the lab of Ben Hall. He pursued postdoctoral studies with Dick Epstein at the Institut de Biologie Moleculaire in Geneva and with Dr. William Rutter at the University of California-San Francisco. He carried out the first molecular cloning of retroviruses at the NIH and also reported the first identification of steroid responsive regulatory elements. Dr. Hager is currently chief of the Laboratory of Receptor Biology and Gene Expression, where his program interests include the role of chromatin structure in gene regulation, the mechanism of steroid receptor function, and the architecture of active genes in the interphase nucleus.
Research Interest
1) Gene regulation, 2) transcription factor dynamics, 3) chromatin structure and function, 4) real time imaging, 5) epigenetics and cancer 6) Cancer Biology, 7) Cell Biology, 8) Chromosome Biology, 9) Genetics and Genomics, 10) Molecular Biology and Biochemistry
Publications
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DNase footprint signatures are dictated by factor dynamics and DNA sequence.
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Transcriptional activation by the thyroid hormone receptor through ligand dependent receptor recruitment and chromatin remodeling.
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Steroid Receptors Reprogram FoxA1 Occupancy through Dynamic Chromatin Transitions.
