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Oncology Experts

Hanqiao Feng

Staff Scientist
Laboratory of Biochemistry and Molecular Biology, CCR
National Cancer Institute
United States of America

Biography

Hanqiao Fengis a Staff Scientist at Laboratory of Biochemistry and Molecular Biology, Center for Cancer Research, National Cancer where studies are focused on the structural basis of how proteins like histone chaperone, liker histones, and chromatin remodelers bind to nucleosome, modulate chromatin structure, mediate the nuclear processes like DNA repair, gene transcription, and ensure accurate segregation of chromosome. We pioneered the structural determination of protein-protein complex and protein in the complex with nucleosome by high-resolution nuclear magnetic resonance (NMR) and X-ray crystallography.

Research Interest

Structural biology, Biophysics, Structural determination of protein-protein complex, Protein-nucleosome complex, NMR, X-ray crystallography, structural determination of protein-protein complex and protein in the complex with nucleosome by high-resolution nuclear magnetic resonance (NMR) and X-ray crystallography.

Publications

  • A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C.

  • Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3.

  • NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2B.

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