Jonathan D. Ashwell
Chief
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Dr. Ashwell received his M.D. from Columbia University College of Physicians and Surgeons. He trained in internal medicine at Presbyterian Hospital in New York City. Following a postdoctoral fellowship in immunology in the laboratory of Dr. Ronald Schwartz (National Institute of Allergy and Infectious Diseases/NIH), Dr. Ashwell joined the NCI as a principal investigator. He was named Chief of the Laboratory of Immune Cell Biology in 1992.
Research Interest
Signal transduction; p38 ; T-cell receptor; T-cell activation; Thymocyte development; Ubiquitination
Publications
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Chuan-Jin W, Conze DB, Li T, Srinivasula SM, Ashwell JD. NEMO is a sensor of Lys 63-linked polyubiquitination and functions in NF-[kappa] B activation. Nature cell biology. 2006 Apr 1;8(4):398.
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Salvador JM, Mittelstadt PR, Guszczynski T, Copeland TD, Yamaguchi H, Appella E, Fornace AJ, Ashwell JD. Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nature immunology. 2005 Apr 1;6(4):390.
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Yang Y, Fang S, Jensen JP, Weissman AM, Ashwell JD. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science. 2000 May 5;288(5467):874-7.
