Oncology
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Oncology Experts

Jonathan M. Hernandez

Investigator
Thoracic and Gastrointestinal Oncology Branch, CCR
National Cancer Institute
United States of America

Jonathan M. Hernandez

Biography

Dr. Hernandez graduated from medical school with honors from the University of Florida, and completed general surgery training at the University of South Florida. During his residency, Dr. Hernandez spent two years at the Moffitt Cancer Center and Research Institute interrogating molecular diagnostics for liver metastases and miRNA-mediated mechanisms of metastatic spread with the support of NIH funding. Following residency, Dr. Hernandez completed fellowship training in both surgical oncology and hepatopancreatobiliary surgery at Memorial Sloan Kettering Cancer Center. During his fellowships, Dr. Hernandez spent an additional two years in dedicated basic research studying metastatic colonization as a scholar in the Cell Biology Program of the Sloan Kettering Institute supported by NIH funding and a grant from America’s HepatoPancreatoBiliary Association. He was also a visiting investigator in the Cell and Developmental Biology Department of Weill Medical College of Cornell University studying metastatic niche evolution with funding support from the Conquer Cancer Foundation of the American Society of Clinical Oncology. Dr. Hernandez has authored over 50 peer-reviewed publications and has contributed book chapters in numerous authoritative surgical textbooks.

Research Interest

1) Hepatopancreatobiliary oncologic surgery 2) pancreatic cancer 3) liver metastasis 4) cholangiocarcinoma 5) metastatic niche 6) cell biology 7) Cancer Biology, 8) Cell Biology

Publications

  • The Rho GTPase Rnd1 suppresses mammary tumorigenesis and EMT by restraining Ras-MAPK signalling.

  • Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver.

  • Tumour exosome integrins determine organotropic metastasis.

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