Joseph J. Barchi Jr.
Senior Scientist
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Dr. Barchi received his Ph.D. in Organic Chemistry from the University of Hawaii with Richard E. Moore and did 2 years of postdoctoral work at Duke University with Bert Fraser-Reid. He then joined the NCI as a staff fellow in 1988, was promoted to staff scientist and then to senior scientist in 2002. His main research interests are in synthetic medicinal chemistry as it relates to carbohydrate-based drug design, and the high-resolution structural analysis of sugars, glycopeptides and small molecule drug candidates by NMR spectroscopy.
Research Interest
Synthetic Organic Chemistry; Carbohydrate/Glycoscience; Small Molecule NMR Spectroscopy
Publications
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Barchi JJ. Mucinâ€Type Glycopeptide Structure in Solution: Past, Present, and Future. Biopolymers. 2013 Oct 1;99(10):713-23.
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Luo M, Velikovsky CA, Yang X, Siddiqui MA, Hong X, Barchi JJ, Gildersleeve JC, Pancer Z, Mariuzza RA. Recognition of the Thomsen-Friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor. Journal of Biological Chemistry. 2013 Aug 9;288(32):23597-606.
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Glinskii OV, Li F, Wilson LS, Barnes S, Rittenhouse-Olson K, Barchi Jr JJ, Pienta KJ, Glinsky VV. Endothelial integrin α3β1 stabilizes carbohydrate-mediated tumor/endothelial cell adhesion and induces macromolecular signaling complex formation at the endothelial cell membrane. Oncotarget. 2014 Mar;5(5):1382.
