Jung Shin Byun
Staff Scientist
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Dr. Jung S. Byun received her Ph.D. in chemistry and biochemistry from the University of Maryland, College Park. She pursued postdoctoral studies with Dr. Kevin Gardner at the National Cancer Institute (NCI), National Institutes of Health (NIH). During her postdoctoral residency, Dr. Byun carried out studies to define how histone acetyltransferase, p300, and the elongation factor, ELL, work in concert to control eukaryotic transcription by demonstrating the role of dynamic bookmarking by p300 RNA polymerase II complexes in transcriptional memory (Byun JS, et al. Proc Natl Acad Sci U S A 2009). She also discovered a new role for ELL (Eleven-nineteen Lysine-rich Leukemia protein), that it is required for early elongation and facilitating pol II pause site entry (Byun JS, et al. Nat Commun 2012). Dr. Byun is currently a staff scientist with Dr. Kevin Gardner’s laboratory. The lab's research interests focus on defining other potential transcription regulatory targets important in mammalian cancer cell biology that define a molecular link between metabolic imbalance and breast cancer.
Research Interest
transcription regulatory targets, cancer cell biology, metabolic imbalance and breast cancer
Publications
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Byun JS, Gardner K. Wounds that will not heal: pervasive cellular reprogramming in cancer. The American journal of pathology. 2013 Apr 30;182(4):1055-64.
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Di LJ, Byun JS, Wong MM, Wakano C, Taylor T, Bilke S, Baek S, Hunter K, Yang H, Lee M, Zvosec C. Genome-wide profiles of CtBP link metabolism with genome stability and epithelial reprogramming in breast cancer. Nature communications. 2013 Feb 5;4:1449.
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Byun JS, Gardner K. C-terminal binding protein: a molecular link between metabolic imbalance and epigenetic regulation in breast cancer. International journal of cell biology. 2013 May 20;2013.
