Cancer and Inflammation Program, CCR
National Cancer Institute
United States of America
Dr. Keqiang Chen obtained his Ph.D. degree in Etiologic Biology from the Second Military Medical University, Shanghai, China, in 2001. In 2002-2003, Dr. Chen studied as a Postdoctoral Fellow at the Medical Center at University of Rochester, NY, USA. In 2004, Dr. Chen joined Dr. Ji Ming Wang’s laboratory in Cancer and Inflammation Program at NCI-Frederick as a Visiting Fellow. In September 2009, Dr. Chen was promoted to the position of Research Fellow at NCI-Frederick. From November 2012, Dr. Chen worked as a Research Scientist at the Department of Biological Sciences, College of Sciences, Virginia Polytechnic Institute and State University (Virginia Tech), in Blacksburg, VA. Dr. Chen was recruited as a Staff Scientist to the Cancer and Inflammation Program, Center for Cancer Research, NCI-Frederick, in June 2016, pursuing his studies of chemoattractant GPCRs in inflammation, immune responses and cancer.
Current research focuses on three major areas to elucidate: 1) the mechanisms by which chemoattractant GPCRs contribute to colonic epithelial homeostasis, inflammation, and tumorigenesis; 2) the mechanisms by which chemoattractant GPCRs regulate the function of myeloid cells in inflammation and anti-tumor host defense; 3) the mechanisms by which chemoattractant GPCRs regulate host and microbiome interaction, 4) leukocyte trafficking 5) chemoattractant GPCR regulation and signaling 6) mouse models of inflammation and cancer.