Center for Cancer Research
National Cancer Institute
United States of America
Dr. Gardner received his B.S. from Yale University and earned his M.D. and Ph.D. from the Johns Hopkins University School of Medicine where he studied the regulation of membrane skeletal proteins in the Department of Cellular Biology and Anatomy. He completed residency training in anatomic pathology at the National Cancer Institute and is board certified in Anatomic Pathology. Dr. Gardner has had a long term interest in the cellular and molecular biology of gene regulation and, while at NIH, has been developing strategies to define pathways and mechanisms of transcriptional control in cancers of lymphoid and epithelial origin. Dr. Gardner is a member of the editorial boards of the American Journal of Pathology the International Journal of Medical Sciences, the Open Clinical Chemistry Journal, the Molecular Cancer Biology Journal, and the American Journal of Translational Research. He is an elected member of the American Society for Clinical Investigation, and was a recipient of an NIH Director's award in 2007 and 2011.
chromatin, transcriptional co-regulators
Di LJ, Fernandez AG, De Siervi A, Longo DL, Gardner K. Transcriptional regulation of BRCA1 expression by a metabolic switch. Nature structural & molecular biology. 2010 Dec 1;17(12):1406-13.
De Siervi A, De Luca P, Byun JS, Di LJ, Fufa T, Haggerty CM, Vazquez E, Moiola C, Longo DL, Gardner K. Transcriptional autoregulation by BRCA1. Cancer research. 2010 Jan 15;70(2):532-42.
Byun JS, Wong MM, Cui W, Idelman G, Li Q, De Siervi A, Bilke S, Haggerty CM, Player A, Wang YH, Thirman MJ. Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes. Proceedings of the National Academy of Sciences. 2009 Nov 17;106(46):19286-91.