Genetics Branch, CCR
National Cancer Institute
United States of America
Dr. Gardner received his B.S. from Yale University and earned his M.D. and Ph.D. from the Johns Hopkins University School of Medicine where he studied the regulation of membrane skeletal proteins in the Department of Cellular Biology and Anatomy. He completed residency training in anatomic pathology at the National Cancer Institute and is board certified in Anatomic Pathology. Dr. Gardner has had a long term interest in the cellular and molecular biology of gene regulation and, while at NIH, has been developing strategies to define pathways and mechanisms of transcriptional control in cancers of lymphoid and epithelial origin. Dr. Gardner is a member of the editorial boards of the American Journal of Pathology the International Journal of Medical Sciences, the Open Clinical Chemistry Journal, the Molecular Cancer Biology Journal, and the American Journal of Translational Research. He is an elected member of the American Society for Clinical Investigation, and was a recipient of an NIH Director's award in 2007 and 2011.
1) The Mechanism of Transcriptional Control by p300-ELL complexes. 2) Transcriptional regulation by BRCA1-associated coregulator complexes. 3) Gene regulatory processes important in the evolution of leukemia and the mechanisms of breast cancer tumor initiation and progression. 4) Mechanisms of gene regulatory control by transcriptional co-regulators
Transcriptional regulation of BRCA1 expression by a metabolic switch.
Transcriptional autoregulation by BRCA1.
Dynamic bookmarking of primary response genes by p300 and RNA polymerase II complexes.