Kirk R. Gustafson
Senior Scientist
Molecular Targets Laboratory, CCR
National Cancer Institute
United States of America
Biography
Dr. Kirk R. Gustafson earned his Ph.D. in organic chemistry from the University of British Columbia in 1984 under the direction of Professor Raymond J. Andersen. From 1984 to 1987 he worked as a postdoctoral fellow with Professor William Fenical at the Scripps Institution of Oceanography. He has a longstanding interest in the isolation, structural determination, and biological characterization of new secondary metabolites produced by terrestrial plants, marine organisms, and microbial isolates. Dr. Gustafson joined the NCI in 1987 and his studies have focused on utilizing the inherent chemical diversity found in natural product sources to help discover new compounds which can serve as biochemical probes or drug leads relevant to cancer and other human diseases.
Research Interest
1) Natural products chemistry 2) NMR spectroscopy 3) Molecular targets 4) High throughput screens 5) Structural elucidation 6) Chemical Biology, 7) Molecular Biology and Biochemistry
Publications
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Nothospondin, a new AP-1 inhibitory quassinoid from the Cameroonian plant Nothospondias staudtii.
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Flavonoids from eight tropical plant species that inhibit the multidrug resistance transporter ABCG2.
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Isolation, structural elucidation, and absolute stereochemistry of enigmazole A, a cytotoxic phosphomacrolide from the Papua New Guinea marine sponge Cinachyrella enigmatica.
