Experimental Transplantation and Immunology Branch, CCR
National Cancer Institute
United States of America
Dr. Gattinoni received his M.D. from the Universita' degli Studi of Milan, Italy. Following the completion of his residency in medical oncology at the Istituto Nazionale Tumori in Milan, he joined the NCI in 2003 as a Visiting Fellow and became a Staff Scientist in 2008. In 2013, Dr. Gattinoni was appointed as an Earl Stadtman Tenure-Track Investigator at the Experimental Transplantation and Immunology Branch. His honors include the 2004 SITC Presidential Award, the 2012 Wilson S. Stone Memorial Award and the 2013 NCI Director’s Intramural Innovation Award. Dr. Gattinoni is an Earl Stadtman investigator at the Experimental Transplantation and Immunology Branch, NCI. He is interested in uncovering the cellular and molecular mechanisms regulating T cell differentiation and the formation and maintenance of immunological memory.
1) Adoptive T cell therapy 2) T memory stem cells 3) Transcriptional factors 4) microRNA 5) Immune metabolism 6) Epigenetic 7) Understanding the transcriptional, metabolic, and microRNA-mediated regulation of T cell self-renewal 8) Multipotency with the goal of developing new T cell-based immunotherapies for the treatment of patients with advanced cancer and hematologic malignancies.
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.
miR-155 augments CD8+ T-cell antitumor activity in lymphoreplete hosts by enhancing responsiveness to homeostatic γc cytokines.
T memory stem cells in health and disease.