Peter D. Aplan
Senior Investigator
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Dr. Aplan received a B.S. in biophysics (1979) and an M.D. (1983) from Pennsylvania State University in 1983. From 1983 to 1987, he trained in pediatrics and was chief resident at the Children's Hospital of Buffalo. He received fellowship training in pediatric hematology/oncology at the NCI from 1987 to 1992 and served as assistant, then associate, professor of pediatrics and microbiology and immunology at Roswell Park Cancer Institute from 1992 to 1999. He moved to the NCI in 1999 where he is an investigator in the Genetics Branch.
Research Interest
myelodysplastic syndrome (MDS); acute myelogenous leukemia (AML); T cell acute lymphoblastic leukemia; chromosomal translocations; templated sequence insertion polymorphisms (TSIPs); genomic instability
Publications
-
Beachy SH, Onozawa M, Chung YJ, Slape C, Bilke S, Francis P, Pineda M, Walker RL, Meltzer P, Aplan PD. Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma. Blood. 2012 Aug 2;120(5):1048-59.
-
Gough SM, Slape CI, Aplan PD. NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights. Blood. 2011 Dec 8;118(24):6247-57.
-
Chung YJ, Choi CW, Slape C, Fry T, Aplan PD. Transplantation of a myelodysplastic syndrome by a long-term repopulating hematopoietic cell. Proceedings of the National Academy of Sciences. 2008 Sep 16;105(37):14088-93.
