Ravi B. Chalamalasetty

Biography

Dr. Ravi Chalamalasetty obtained his Ph.D. in cell biology in the laboratory of Prof. Dr. Erich A. Nigg at Max Planck Institute for Biochemistry in Munich, Germany in 2006. Dr. Chalamalasetty studied the mechanisms of mammalian cytokinesis and was mentored by Dr. Erich A. Nigg and Dr. Herman Sillje. He received the Max Planck Fellowship for Doctoral Students from 2002-2006. For postdoctoral studies, he joined the Cancer and Developmental Biology Laboratory at the National Cancer Institute at Frederick in Dr. Terry Yamaguchi’s lab as a visiting fellow. Since 2015, he has served as a Staff Scientist at the National Cancer Institute at Frederick.

Research Interest

1) embryonic development, 2) embryonic stem cells, 3) mouse genetics, 4) genomics, 5) Wnt signaling, 6) transcription factors, 5) To understand how Wnts regulate self-renewal of stem cells and at the same time essential for cell-fate determination and differentiation, 6) To understand the molecular cross-talk of Wnt signals with other signaling pathways such as FGF, Notch-Delta and BMP signaling during embryonic development and cell fate determination 7) To delineate gene-regulatory network by identifying molecular mechanisms at the level of Wnt regulated transcription factors. 8) To understand the molecular mechanisms of developmentally regulated genes in cancer initiation and progression.