Oncology Experts

Richard J. Hodes

Senior Investigator
Experimental Immunology Branch, Immune Regulation Section,
National Cancer Institute
United States of America


Dr. Hodes received his M.D. from Harvard Medical School and completed a research fellowship at the Karolinska Institute in Stockholm and clinical training in internal medicine at Massachusetts General Hospital before coming to the NIH. He is chief of the Immune Regulation Section of the Experimental Immunology Branch as well as director of the National Institute on Aging. Richard Hodes’ lab studies regulation of the development and function of the adaptive immune system. Ongoing work is focused on the role of T cell receptor and co-stimulatory signals in thymic development and T cell-dependent immune responses, and on the maintenance of chromosomal integrity and proliferative capacity during lymphocyte development and activation.

Research Interest

1) Thymus development 2) T cell receptor 3) Costimulation 4) Tumor suppressor p53 5) Ataxia telangiectasia mutated 6) Cell Biology, 7) Immunology


  • Identification of an alternative CTLA-4 ligand costimulatory for T cell activation

  • TRAF3 enforces the requirement for T cell cross-talk in thymic medullary epithelial development

  • Downmodulation of Tumor Suppressor p53 by T Cell Receptor Signaling Is Critical for Antigen-Specific CD4(+) T Cell Responses

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