Ruth A. Kleinerman
Deputy Branch Chief and Staff Scientist
Division of Cancer Epidemiology & Genetics, Radiation Epidem
National Cancer Institute
United States of America
Biography
Dr. Kleinerman received a B.A. from Washington University, an M.P.H. from Boston University School of Public Health, and a Ph.D. from the University of London, U.K. Dr. Kleinerman joined the NCI Epidemiology and Biostatistics Program in 1979. Currently, she is Deputy Branch Chief of the Radiation Epidemiology Branch. As lead of the large follow-up study of late effects in adult survivors of retinoblastoma with a focus on the risk of second cancers, Dr. Kleinerman identified for the first time that hereditary retinoblastoma survivors with an inherited germline RB1 mutation are at higher risk of a second cancer, especially melanoma, compared to hereditary retinoblastoma survivors with a de novo germline RB1 mutation. She has received the NIH Merit Award as well as two NCI DCEG awards for Outstanding Research Paper by a Staff Scientist based on her research on retinoblastoma survivors. Through her research, she has identified new risks of specific second cancers in retinoblastoma survivors. Her interest in second cancers has led her to collaborate on a large study of second gastrointestinal cancers following radiotherapy for cervical cancer, which builds on her earlier research on second cancers following radiation for cervical cancer.
Research Interest
Retinoblastoma; Cancer mortality in physicians conducting fluoroscopically-guided procedures
Publications
-
Kleinerman RA, Wang Z, Wang L, Metayer C, Zhang S, Brenner AV, Zhang S, Xia Y, Shang B, Lubin JH. Lung cancer and indoor exposure to coal and biomass in rural China. Journal of occupational and environmental medicine. 2002 Apr 1;44(4):338-44.
-
Kleinerman RA. Radiation-sensitive genetically susceptible pediatric sub-populations. Pediatric radiology. 2009 Feb 1;39(1):27-31.
-
Kleinerman RA, Tucker MA, Abramson DH, Seddon JM, Tarone RE, Fraumeni Jr JF. Risk of soft tissue sarcomas by individual subtype in survivors of hereditary retinoblastoma. Journal of the National Cancer Institute. 2007 Jan 3;99(1):24-31.
