Scott K. Durum
Senior Investigator
Cancer and Inflammation Program, CCR
National Cancer Institute
United States of America
Biography
Scott K. Durum is Senior Investigator at Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute. After receiving his Ph.D. in 1978, Dr. Durum received his postdoctoral training in immunology at the National Jewish Hospital in Denver and at Yale Medical School. Dr. Durum joined the Laboratory of Molecular Immunoregulation in 1984. Dr. Durum's research is aimed at determining the mechanism of action of IL-7, a cytokine that is essential for T cell development and survival. Understanding the IL-7 pathways has given sights into the physiology of lymphocytes, suggested therapeutic strategies for modulating immunity, and revealed mechanisms of leukemogenesis
Research Interest
1) Interleukin-7 (IL-7), 2) Immunity, 3) Leukemogenesis, 4) Determine the mechanism of action of IL-7, a cytokine that is essential for T cell development and survival 5) Characterize the extensive processes containing the IL-7 reporter 6) investigate chronic inflammatory processes that predispose to carcinogenesis, 7) Cancer Biology, 8) Cell Biology, 9) Immunology
Publications
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Targeting interleukins for the treatment of inflammatory bowel disease-what lies beyond anti-TNF therapy?
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Oral delivery of IL-27 recombinant bacteria attenuates immune colitis in mice.
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Chronic exposure to type-I IFN under lymphopenic conditions alters CD4 T cell homeostasis.