Shyam K. Sharan
Deputy Program Director
Mouse Cancer Genetics Program
National Cancer Institute
United States of America
Biography
Dr. Sharan obtained his B.Sc. in botany and M.Sc. in genetics from Delhi University, Delhi. In 1994, he obtained his Ph.D. in genetics under Dr. Terry Magnuson at Case Western Reserve University. He then joined Dr. Allan Bradley's laboratory at Baylor College of Medicine as a Howard Hughes Medical Institute Associate. In 1998, Dr. Sharan established the Genetics of Cancer Susceptibility Group in the ABL-Basic Research Program. His group is involved in the functional analysis of tumor suppressor genes in mice. In 1999, Dr. Sharan joined the Center for Cancer Research, NCI. In 2008, Dr. Sharan received the NCI Director's Intramural Innovation Award and in 2009 he received the NIH merit award and the Arthur Flemming Award for his work on functional analysis of BRCA1 and BRCA2. Dr. Sharan is also the Scientific Director of the Center for Advanced Preclinical Research (CAPR).
Research Interest
1) DNA repair 2) hereditary breast cancer 3) tumor suppressor 4) mouse models 5) recombineering 6) BRCA1/2 variants
Publications
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Thirthagiri E, Klarmann KD, Shukla AK, Southon E, Biswas K, Martin BK, North SL, Magidson V, Burkett S, Haines DC, Noer K. BRCA2 minor transcript lacking exons 4–7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation. Human molecular genetics. 2016 Feb 26;25(10):1934-45.
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Hartford SA, Chittela R, Ding X, Vyas A, Martin B, Burkett S, Haines DC, Southon E, Tessarollo L, Sharan SK. Interaction with PALB2 is essential for maintenance of genomic integrity by BRCA2. PLoS genetics. 2016 Aug 4;12(8):e1006236.
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Ding X, Chaudhuri AR, Callen E, Pang Y, Biswas K, Klarmann KD, Martin BK, Burkett S, Cleveland L, Stauffer S, Sullivan T. Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies. Nature communications. 2016 Aug 8;7.
