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Oncology Experts

Steven A. Rosenberg

Senior Investigator
Surgery Branch, Tumor Immunology Section, CCR
National Cancer Institute
United States of America

Biography

Dr. Steven A. Rosenberg is Chief of Surgery at the National Cancer Institute in Bethesda, Maryland and a Professor of Surgery at the Uniformed Services University of Health Sciences and the George Washington University School of Medicine and Health Sciences. He received his B.A. and M.D. degrees at Johns Hopkins University and a Ph.D. in Biophysics at Harvard University. After completing his residency training in surgery in 1974 at the Peter Bent Brigham Hospital in Boston, Massachusetts, Dr. Rosenberg became the Chief of Surgery at the NCI, NIH, a position he has held to the present time. Dr. Rosenberg developed the first effective immunotherapies and gene therapies for patients with advanced cancer. His studies of cell transfer immunotherapy have resulted in durable complete remissions in patients with metastatic melanoma. He was the first to successfully insert foreign genes into humans and his recent studies of the adoptive transfer of genetically modified lymphocytes has resulted in the regression of metastatic cancer in patients with melanoma, sarcomas and lymphomas.

Research Interest

1) Cancer immunotherapy 2) Tumor-infiltrating lymphocytes 3) Cancer antigens 4) T cell receptors 5) Metastatic melanoma 6) Gene therapy 7) Cancer Biology, 8) Clinical Research, 9) Immunology

Publications

  • Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer.

  • T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer.

  • 'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations.

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