Steven D. Cappell
Investigator
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Dr. Cappell received his B.S. in marine science and Bbiology from the University of Miami, FL. He obtained his Ph.D. from the University of North Carolina, Chapel Hill, where he studied G protein signaling in yeast in the lab of Dr. Henrik Dohlman. He completed his postdoctoral training as a Damon Runyon Cancer Research Foundation Fellow in the laboratory of Dr. Tobias Meyer at Stanford University. His postdoctoral research focused on understanding how cells make the decision to divide.
Research Interest
signal transduction, systems biology, cell cycle, single-cell analysis, fluorescent biosensors, ubiquitin ligases
Publications
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Torres MP, Clement ST, Cappell SD, Dohlman HG. Cell cycle-dependent phosphorylation and ubiquitination of a G protein α subunit. Journal of Biological Chemistry. 2011 Jun 10;286(23):20208-16.
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Spencer SL, Cappell SD, Tsai FC, Overton KW, Wang CL, Meyer T. The proliferation-quiescence decision is controlled by a bifurcation in CDK2 activity at mitotic exit. Cell. 2013 Oct 10;155(2):369-83.
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Cappell SD, Chung M, Jaimovich A, Spencer SL, Meyer T. Irreversible APC Cdh1 Inactivation Underlies the Point of No Return for Cell-Cycle Entry. Cell. 2016 Jun 30;166(1):167-80.
