Center for Cancer Research
National Cancer Institute
United States of America
Dr. Gottesman received her Ph.D. from the Department of Microbiology at Harvard University and became a postdoctoral fellow at the NIH. She then went to the Massachusetts Institute of Technology (MIT) as a research associate and returned to the NIH in 1976 as a senior investigator in the Laboratory of Molecular Biology, where she has remained. She was elected to the National Academy of Sciences in 1998 and the American Academy of Arts and Sciences in 1999. She received the Abbott-ASM Lifetime Achievement Award in 2011.
1) microbial genetics 2) bacterial regulatory RNAs 3) ATP-dependent proteolysis
Soper T, Mandin P, Majdalani N, Gottesman S, Woodson SA. Positive regulation by small RNAs and the role of Hfq. Proceedings of the National Academy of Sciences. 2010 May 25;107(21):9602-7.
Zhang A, Schu DJ, Tjaden BC, Storz G, Gottesman S. Mutations in interaction surfaces differentially impact E. coli Hfq association with small RNAs and their mRNA targets. Journal of molecular biology. 2013 Oct 9;425(19):3678-97.
Battesti A, Hoskins JR, Tong S, Milanesio P, Mann JM, Kravats A, Tsegaye YM, Bougdour A, Wickner S, Gottesman S. Anti-adaptors provide multiple modes for regulation of the RssB adaptor protein. Genes & development. 2013 Dec 15;27(24):2722-35.