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Terrence R. Burke

Senior Investigator
Chemical Biology Laboratory, Bioorganic Chemistry Section
National Cancer Institute
United States of America


Dr. Terrence R. Burke received his B.S. in Chemistry from St. Martin's College, followed by his Ph.D. degree from the University of Washington under the direction of Professor Wendel Nelson. He then studied as a Fellow of the Pharmacology Associate Research Training Program in the Laboratory of Dr. Lance Pohl, National Heart Lung and Blood Institute and subsequently under the direction of Dr. Kenner Rice as a Senior Staff Fellow of the National Institute of Diabetes, Digestive and Kidney Diseases. He briefly left the NIH to serve as Principal Chemist of Peptide Technologies Corporation before returning in 1989 as a tenured Principal Investigator in the Chemical Biology Laboratory (previously, the Laboratory of Medicinal Chemistry). In 2002 he became Head of the Bioorganic and Medicinal Chemistry Section and in 2003 he was appointed a member of the Senior Biomedical Research Service (SBRS).

Research Interest

1) Bioorganic and medicinal chemistry, 2) Peptide and peptide mimetic chemistry, 3) Inhibitors of phospho-dependent protein-protein interactions (PPIs), 4) HIV integrase inhibitors, 5) Antibody-drug conjugates (ADCs), 6) Protein-tyrosine phosphatase inhibitors; 7) Bioorganic Medicinal Chemistry and the Modulation of Kinase-Dependent Signal Transduction; 8) Chemical Biology, 9) Molecular Biology and Biochemistry, 10) Molecular Pharmacology, 11) Structural Biology,12) Virology.

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