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Thomas Ried

Senior Investigator
Genetics Branch, CCR
National Cancer Institute
United States of America

Thomas Ried

Biography

Dr. Ried received his M.D. from the Max Planck Institute for Medical Research in Heidelberg, Germany. After having completed his postdoctoral training at the University of Leiden and at Yale University, he joined the faculty of the National Human Genome Research Institute in 1994. Dr. Ried became an investigator at the NCI in 1998 and a senior investigator and Chief of the Cancer Genomic Section in 2002. Since 1998 he has co-directed the Cancer Chromosome Aberration Project. In 2000, Dr. Ried received the AMGEN award of the American Society of Biochemistry and Molecular Biology. Dr. Ried serves as a member of the editorial board for numerous scientific journals. Dr. Ried pioneered the development of molecular cytogenetic techniques, including spectral karyotyping (SKY) and their applications to understanding the dynamics of genomic alterations during the development of solid tumors, with an emphasis on breast, cervical and colorectal carcinomas.

Research Interest

1) Molecular cytogenetics 2) chromosomal instability 3) cervical cancer 4) colorectal cancer 5) gene expression 6) Cancer Biology, 7) Chromosome Biology, 8) Genetics and Genomics, 9) Systems Biology.

Publications

  • Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability.

  • Cancer driver-passenger distinction via sporadic human and dog cancer comparison: a proof-of-principle study with colorectal cancer.

  • Algorithms to model single gene, single chromosome, and whole genome copy number changes jointly in tumor phylogenetics.

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