Tom Misteli
Director, Center for Cancer Research
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Tom Misteli is an internationally renowned pioneer in the field of genome cell biology. He trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. His laboratory aims to uncover fundamental principles of higher order genome organization and to apply this knowledge to the development of novel diagnostic and therapeutic strategies for cancer and aging. He has received numerous awards for his work, acts as an advisor for several national and international agencies and serves on numerous editorial boards. He has received numerous awards including the Gian Tondury Award, the Gold Medal of The Charles University, the 2012 Flemming Award, The Wilhem Bernhard Medal and the Herman Beerman Award.
Research Interest
1) chromosomes, 2) chromatin, 3) cell nucleus, 4) nuclear architecture, 5) imaging, 6) epigenetics
Publications
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Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T. Regulation of alternative splicing by histone modifications. Science. 2010 Feb 19;327(5968):996-1000.
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Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T. Spatial dynamics of chromosome translocations in living cells. Science. 2013 Aug 9;341(6146):660-4.
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Shachar S, Voss TC, Pegoraro G, Sciascia N, Misteli T. Identification of gene positioning factors using high-throughput imaging mapping. Cell. 2015 Aug 13;162(4):911-23.
