Wendy D. Dubois
Senior Investigator
Laboratory of Cancer Biology and Genetics, CCR
National Cancer Institute
United States of America
Biography
Wendy D. DuBois is a Senior Investigator at Laboratory of Cancer Biology and Genetics, Centre for Cancer Research and also he is head of Animal Model and Genotyping Core Facility, National Cancer Institute. The LCBG Animal Model and Genotyping Core Facility provides outstanding, reliable research support to a number of NCI intramural investigators. The Facility's mission is to create and maintain mouse models for various cancers including: - B cell lymphomas, - plasma cell tumors, - myeloma, - skin carcinogenesis and melanoma, - breast cancer, and - prostate cancer. The Core also performs a variety of genomic analyses in support of investigators. The Facility's Genomics Section provides assistance both to LCBG investigators and to other CCR investigators as appropriate, for a wide variety of genomic applications including, but not limited to: - database mining, - marker development, - single nucleotide polymorphism (SNP) identification and analysis, and - sequencing and sequence homology searches. Programs currently supported by the Core include MacVector, DS Gene, Vector NTI, LaserGene, Sequencher, Partek, and Ingenuity Pathway Analysis.
Research Interest
Genotyping, Experiment design, Colony management, Cancer Biology, Genetics and Genomics
Publications
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Cooperative Targets of Combined mTOR/HDAC Inhibition Promote MYC Degradation.
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cFOS-SOX9 Axis Reprograms Bone Marrow-Derived Mesenchymal Stem Cells into Chondroblastic Osteosarcoma.
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Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression.