Xinguo Chen
Staff Scientist
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Dr. Xinguo Chen obtained his Ph.D. from the University of Düsseldorf in Germany in 1998. He then joined Dr. Sandra Wolin's lab, Department of Cell Biology, Yale University School of Medicine as a Postdoctoral Associate from 1998 to 2001. In 2001, he was appointed as an Associate Research Scientist. From 2013 to 2017, he was appointed as a Research Scientist. He is currently a Staff Scientist in Sandra Wolin’s laboratory. His research interest is to study the biogenesis and regulation of noncoding RNAs and the function of RNA-protein complexes in cells. His contributions to the RNA field include the discovery of a new bacterial RNA degradation machine called RYPER, the discovery of new roles for noncoding RNAs, and the discovery of a new class of bacterial Y RNAs that are tRNA mimics.
Research Interest
noncoding RNA biogenesis and function, RNA-protein interactions, exo- and endoribonucleases, RNA processing and decay, RNA damage response
Publications
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Chen X, Taylor DW, Fowler CC, Galan JE, Wang HW, Wolin SL. An RNA degradation machine sculpted by Ro autoantigen and noncoding RNA. Cell. 2013 Mar 28;153(1):166-77.
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Chen X, Sim S, Wurtmann EJ, Feke A, Wolin SL. Bacterial noncoding Y RNAs are widespread and mimic tRNAs. RNA. 2014 Nov 1;20(11):1715-24.
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Schmier BJ, Chen X, Wolin S, Shuman S. Deletion of the rnl gene encoding a nick-sealing RNA ligase sensitizes Deinococcus radiodurans to ionizing radiation. Nucleic acids research. 2017 Apr 20;45(7):3812-21.
