RNA Biology Laboratory, CCR
National Cancer Institute
United States of America
Dr. Xinguo Chen obtained his Ph.D. from the University of Düsseldorf in Germany in 1998. He then joined Dr. Sandra Wolin's lab, Department of Cell Biology, Yale University School of Medicine as a Postdoctoral Associate from 1998 to 2001. In 2001, he was appointed as an Associate Research Scientist. From 2013 to 2017, he was appointed as a Research Scientist. He is currently a Staff Scientist in Sandra Wolin’s laboratory. His research interest is to study the biogenesis and regulation of noncoding RNAs and the function of RNA-protein complexes in cells. His contributions to the RNA field include the discovery of a new bacterial RNA degradation machine called RYPER, the discovery of new roles for noncoding RNAs, and the discovery of a new class of bacterial Y RNAs that are tRNA mimics.
1) Noncoding RNA biogenesis and function 2) RNA-protein interactions 3) exo- and endoribonucleases 4) RNA processing and decay 5) RNA damage response 6) identifying the roles of an abundant class of ribonucleoproteins (RNPs) 7) Cell Biology, 8) Microbiology and Infectious Diseases, 9) Molecular Biology and Biochemistry 10) biogenesis and regulation of noncoding RNAs