Yoshimi Endo Greer
Center for Cancer Research
National Cancer Institute
United States of America
Dr. Yoshimi Greer obtained her M.D. in 1994 from Tohoku University School of Medicine in Sendai, Japan. After graduation, she conducted her clinical residency training in internal medicine at Tohoku University Hospital for 5 years. Dr. Greer obtained a Ph.D. in renal physiology in 1999 at the Graduate School of Tohoku University; her dissertation research focused on the role of the Ang II receptor blocker on micro-hemodynamics in animal kidney model systems. Dr. Greer joined Dr. Josephine P. Briggs' lab at the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) as a postdoctoral fellow in 1998 where she studied the transcriptional regulatory mechanism of COX-2. In 2001, Dr. Greer joined Dr. Jeff Rubin's lab at the NCI-CCR. While in Dr. Rubin’s lab, she studied the molecular mechanism of Wnt3a-dependent cell motility in mammalian cells. In 2004, Dr. Greer joined Georgetown University Medical School as a research instructor (junior faculty) and studied the transcriptional mechanism of VE-cadherin that is involved with retinoic acid-mediated trans-differentiation of breast cancer cells. In 2006, Dr. Greer returned to NCI as a research fellow and continued her Wnt signal research. She discovered the molecular mechanisms that explain how Wnt-3a stimulates neurite outgrowth in Ewing tumor cells. In 2009, she became a staff scientist in the Laboratory of Cellular and Molecular Biology, CCR . She identified casein kinase 1 delta, a kinase involved in Wnt signaling, that plays an essential role in neurite outgrowth, ciliogenesis and DNA damage control. In October 2014, she joined Dr. Stan Lipkowitz’s lab because she has a great interest in translational research. Dr. Greer is now studying TRAIL-induced cell death mechanism in breast cancer cells.
1) signal transduction, 2) breast cancer, 3) apoptosis, 4) DNA damage 5) cell cycleGreer YE, Gao B, Yang Y, Nussenzweig A, Rubin JS. Lack of Casein Kinase 1 Delta Promotes Genomic Instability-The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. PloS one. 2017 Jan 26;12(1):e0170903.
Greer YE, Fields AP, Brown AM, Rubin JS. Atypical protein kinase Cι is required for Wnt3a-dependent neurite outgrowth and binds to phosphorylated Dishevelled 2. Journal of Biological Chemistry. 2013 Mar 29;288(13):9438-46.
Greer YE, Westlake CJ, Gao B, Bharti K, Shiba Y, Xavier CP, Pazour GJ, Yang Y, Rubin JS. Casein kinase 1δ functions at the centrosome and Golgi to promote ciliogenesis. Molecular biology of the cell. 2014 May 15;25(10):1629-40.
Greer YE, Gao B, Yang Y, Nussenzweig A, Rubin JS. Lack of Casein Kinase 1 Delta Promotes Genomic Instability-The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1. PloS one. 2017 Jan 26;12(1):e0170903.