Yves Pommier
Chief
Center for Cancer Research
National Cancer Institute
United States of America
Biography
Dr. Pommier received his M.D. and Ph.D. degrees from the University of Paris, France, and has been at the NIH since 1981. Dr. Pommier is the chief of the Developmental Therapeutics Branch (formerly the Laboratory of Molecular Pharmacology), the co-chair of the Discovery Committee of the NCI Experimental Therapeutics Program and member of the Molecular Target steering committee at the Center for Cancer Research, NCI. Dr. Pommier is also honorary professor of the Shanghai Institute Materia Medica, Chinese Academy of Sciences and adjunct member of the NCI Developmental Therapeutics Program (NCI-DTP). Dr. Pommier has received an NIH Merit Award for his role in elucidating the function of topoisomerases as targets for anticancer drugs and Federal Technology Transfer awards for studies on HIV-1 integrase and DNA topoisomerase inhibitors. Dr. Pommier serves as senior editor for the therapeutics, targets, and chemical biology sections of Cancer Research. He also served as chair for the 2004-2005 Gordon conferences on the molecular therapeutics of cancer and organized the international conferences on retroviral integrase: molecular biology and pharmacology in 1995, 2001, 2008, 2011 and 2014. Dr. Pommier received the Paul Ehrlich Lecture Award from the Societe de Chimie Therapeutique in 2005. Dr. Pommier has authored more than 550 publications and holds over 20 patents for inhibitors of DNA topoisomerases, tyrosyl-DNA phosphodiesterase, checkpoint inhibitors and HIV-1 integrase inhibitors.
Research Interest
1) DNA topoisomerases, 2) DNA repair, 3) cell cycle checkpoints, 4) HIV integrase, 5) mitochondria
Publications
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Murai J, Shar-yin NH, Das BB, Renaud A, Zhang Y, Doroshow JH, Ji J, Takeda S, Pommier Y. Trapping of PARP1 and PARP2 by clinical PARP inhibitors. Cancer research. 2012 Nov 1;72(21):5588-99.
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Zoppoli G, Regairaz M, Leo E, Reinhold WC, Varma S, Ballestrero A, Doroshow JH, Pommier Y. Putative DNA/RNA helicase Schlafen-11 (SLFN11) sensitizes cancer cells to DNA-damaging agents. Proceedings of the National Academy of Sciences. 2012 Sep 11;109(37):15030-5.
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Kim N, Shar-yin NH, Williams JS, Li YC, Clark AB, Cho JE, Kunkel TA, Pommier Y, Jinks-Robertson S. Mutagenic processing of ribonucleotides in DNA by yeast topoisomerase I. Science. 2011 Jun 24;332(6037):1561-4.
