Brian P Brooks
Senior Investigator and Clinical Director
Pediatric, Developmental & Genetic Ophthalmology Unit
National Eye Institute
United States of America
Biography
Dr. Brooks graduated summa cum laude, with general honors and honors in zoology, from the University of Maryland. He was supported during his training in the MD, PhD. program at the University of Pennsylvania by the Medical Scientist Training Program. Residency training in ophthalmology and a fellowship in pediatric ophthalmology were completed at the University of Michigan. Dr. Brooks completed a fellowship in medical genetics at the National Human Genome Research Institute and is board-certified by the American College of Medical Genetics and the American Board of Ophthalmology. He has published numerous articles and book chapters on the genetics of eye disease and has received numerous awards, including the Presidential Early Career Award for Science and Engineering (PECASE), the nation’s highest honor for young investigators.
Research Interest
Hid research mainly focused on causes and mechanisms of inherited eye diseases—especially those that affect children.Currently, his lab is focused on two diseases: 1) uveal coloboma and 2) albinism.
Publications
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George A, Zand DJ, Hufnagel RB, Sharma R, Sergeev YV, Legare JM, Rice GM, Schwoerer JA, Rius M, Tetri L, Gamm DM. Biallelic Mutations in MITF Cause Coloboma, Osteopetrosis, Microphthalmia, Macrocephaly, Albinism, and Deafness. The American Journal of Human Genetics. 2016 Dec 1;99(6):1388-94.
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Brown JD, Dutta S, Bharti K, Bonner RF, Munson PJ, Dawid IB, Akhtar AL, Onojafe IF, Alur RP, Gross JM, Hejtmancik JF. Expression profiling during ocular development identifies 2 Nlz genes with a critical role in optic fissure closure. Proceedings of the National Academy of Sciences. 2009 Feb 3;106(5):1462-7.
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Onojafe IF, Adams DR, Simeonov DR, Zhang J, Chan CC, Bernardini IM, Sergeev YV, Dolinska MB, Alur RP, Brilliant MH, Gahl WA. Nitisinone improves eye and skin pigmentation defects in a mouse model of oculocutaneous albinism. The Journal of clinical investigation. 2011 Oct 3;121(10):3914.
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Alur RP, Vijayasarathy C, Brown JD, Mehtani M, Onojafe IF, Sergeev YV, Boobalan E, Jones M, Tang K, Liu H, Xia CH. Papillorenal syndrome-causing missense mutations in PAX2/Pax2 result in hypomorphic alleles in mouse and human. PLoS genetics. 2010 Mar 5;6(3):e1000870.
