United States of America
As one of the most respected leaders in the field of molecular cell biology, Dr. David M. Sabatini has spent his career delving deeply into the mechanisms that regulate cell growth. His seminal research has focused on the mTOR (mechanistic target of rapamycin) pathway, a critical regulator of cellular growth. His work includes the discovery of most of the protein components of the mTOR pathway, including mTOR itself, and ongoing investigation of their functions in diseases such as cancer and diabetes as well as in aging. Dr. Sabatini’s passion for the field is evident in his research, speeches, awards and dozens of scientific papers that have been published related to mTOR and its role in growth control. Dr. Sabatini began his career as a 24-year-old MD-PhD student who joined The Johns Hopkins University lab of neuroscientist Solomon Snyder in the early 1990s. Given the opportunity to choose his research project, he chose the study of the rapamycin molecule. While still a student at Johns Hopkins, Dr. Sabatini discovered mTOR and the mode of action of rapamycin in 1994. This was the first of his many contributions to the field as, according to Dr. Snyder, “more than 90 percent of the discoveries that have made mTOR one of the hottest proteins in the world have largely been attributed to his work.”
His seminal research has focused on the mTOR (mechanistic target of rapamycin) pathway, a critical regulator of cellular growth.