John Cullen

Biography

Course Involvement: VMP 931: General Pathology. VMP 941: Systemic Pathology. VMP 991D: Necropsy Pathology Selective. VMP 977: Clinical Laboratory/Necropsy. VMP 991M: Surgical Pathology Selective. VMM 991K: Selective in Nondomestic Animal Pathology. CBS 804: Seminar in Necropsy Pathology. CBS 803: Seminar in Surgical Pathology. CBS 810F: Pathology Concentration Seminar. Graduate Courses: CBS 565: Fundamentals of Biomedical Sciences. ---- I have been at NCSU CVM for more than 30 years active in teaching, service and research. My early training occurred at the University of Pennsylvania for undergarduate and veterinary school. After a small animal internship at Angell Memorial Animal Hospital and a brief stint as a small animal practitioner I entered a combined residency/PhD program at UC Davis. I have been at NCSU ever since working in various aspects of liver disease, both spontaneous and experimental. Animal models of viral hepatitis have been my main emphasis over the last number of years. AFFILIATIONS: AVMA, ACVP, AASLD. CERTIFICATIONS: Diplomate, American College of Veterinary Pathology. Fellow, International Academy of Toxicologic Pathologists. VMD, University of Pennsylvania. PhD, University of California at Davis. Diplomate: American College of Veterinary Pathology. Fellow: International Academy of Toxicologic Pathologists.

Research Interest

INFECTIOUS DISEASES, SPONTANEOUS ANIMAL DISEASE MODELS: Research Area: drug-induced hepatic disease, animal models of viral hepatitis. Current Research: Animal Models of Hepatitis C virus and Hepatic toxicity with the Comparisons of acute hepatotoxicity in conventional and germ free mice, Acute biliary toxicity in IL-10 k.o. mice, Acute biliary toxicity in Kupffer cell depleted mice, and Acute gene expression in biliary epithelia following oral ANIT exposure ---- My focus is diseases of the liver. I have worked primarily with models of viral hepatitis, but am also engaged in studies of hepatic toxicity.