Ronald Baynes
professor
DEPARTMENT OF POPULATION HEALTH AND PATHOBIOLOGY
North Carolina State University
United States of America
Biography
Course Involvement: VMA 933: Introduction to Pharmacology, VMA 943: Pharmacology and Veterinary Therapeutics, VMP 992: Food Animal Residue Avoidance Databank, VMP 991: Skin Pharmacology and Toxicology. Graduate Courses: TOX 701: General Toxicology: Pharmacokinetics and Risk Assessment, CBS 565: Fundamentals of Biomedical Sciences: Pharmacokinetic and Pharmacodynamics, CBS 787 Pharmacokinetics, CBS 762 Principles of Pharmacology. Undergraduate Courses: ALS 498H: Honors Research in Agriculture and Life Sciences. AFFILIATIONS: American Chemical Society, Society of Toxicology, American Academy of Veterinary Pharmacology and Therapeutics, Sigma Xi. CERTIFICATIONS: DVM, Tuskegee University; PhD, Pharmacology, North Carolina State University; MS, Pharmacology, University of Georgia; BSc, Biology, University of the West Indies.
Research Interest
PHARMACOLOGY: Dermal Absorption Assessment: The focus of my research is to determine physiochemical and chemical-biological interactions in epidermal corneocytes and intercellular lipids in the epidermis that can influence dermal absorption of complex mixtures. Dermal Absorption: Current research activities are focused on assessing the dermal disposition of cutting fluid and jet fuel additives and pesticides. This research is providing some understanding of the physicochemical factors influencing dermal absorption of these pesticides and formulation additives that cause occupational irritant dermatitis. Other work is focused on understanding transdermal delivery of avermectins across skin various food animal species. HPLC and GC analytical methods are continually being developed. Residue Pharmacology and Risk Assessment of Veterinary Drugs: Current Research and Extension Activities are focused on providing expert consultation to veterinarians and livestock farmers about drug/chemical residues in livestock, development of algorithms for estimating safe withdrawal times, development of provisional acceptable residues as temporary safe levels in animal-derived food, and development of residue monitoring and residue avoidance programs internationally (gFARAD). The laboratory has been active in HPLC analytical method development for antibiotic residues in milk.
Publications
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Application of risk assessment and management principles to the extralabel use of drugs in food-producing animals.Gehring R, Baynes RE, Riviere JE: | Journal of Veterinary Pharmacology and Therapeutics 29: 5-14, 2006.
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Chemical Risk Assessment.Baynes RE, Buur JL: | In Biological Concepts and Techniques in Toxicology, (Ed. JE Riviere), Taylor and Francis Chapter 7, pp. 93-116, 2006.
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(2009). A physiologically based pharmacokinetic model linking plasma protein binding interactions with drug disposition.Buur, J.L., Baynes, R.E., Smith, G.W., and Riviere, J.E. | Res Vet Sci 86:293-301.
