Irina V Budunova
Associate Professor of Dermatology and Urology
Department of Dermatology
Northwestern University Feinberg School of Medicine
United States of America
Biography
Our research is focused on the role of the glucocorticoid receptor (GR) and its target genes in skin and prostate tumor development, and regulation of stem cells. We are also very much interested in translational aspects of the GR biology, and my laboratory has been involved in the development of novel selective GR activators (SEGRA) that preserve therapeutic potential of glucocorticoids but have fewer side effects. We also study the molecular mechanisms of the major side effect of topical glucocorticoids - skin atrophy using mice with knockout of identified GR target genes.
Research Interest
Skin Cancer, Chemotherapy, Prostate Cancer
Publications
-
Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids Kishibe M, Baida G, Bhalla P, Lavker RM, Schlosser B, Iinuma S, Yoshida S, Dudley JT, Budunova I Oncotarget. 2016 Jan; 7(43): 69479-69488. doi:http://dx.doi.org/10.18632/oncotarget.9926. PMID: 27283773 PMCID: 27283773 ISSN: 1949-2553
-
N-bromotaurine surrogates for loss of antiproliferative response and enhances cisplatin efficacy in cancer cells with impaired glucocorticoid receptor Logotheti S, Khoury N, Vlahopoulos SA, Skourti E, Papaevangeliou D, Liloglou T, Gorgoulis V, Budunova I, Kyriakopoulos AM, Zoumpourlis V Translational Research. 2016 Jul; 173: 58-73.e2. doi:http://dx.doi.org/10.1016/j.trsl.2016.03.009. PMID: 27063960 ISSN: 1931-5244
-
Endogenous Glucocorticoid Deficiency in Psoriasis Promotes Inflammation and Abnormal Differentiation Sarkar MK, Kaplan N, Tsoi LC, Xing X, Liang Y, Swindell WR, Hoover P, Aravind M, Baida G, Clark M, Voorhees JJ, Nair RP, Elder JT, Budunova I, Getsios S, Gudjonsson JE Journal of Investigative Dermatology. 2017 Jul; 137(7): 1474-1483. doi:http://dx.doi.org/10.1016/j.jid.2017.02.972. PMID: 28259685 PMCID: 28259685 ISSN: 0022-202X
