Jindan Yu
Professor of Medicine (Hematology and Oncology) an
Department of Biochemistry and Molecular Genetics
Northwestern University Feinberg School of Medicine
United States of America
Biography
The primary research focus of the lab is to understand aberrant transcriptional and epigenetic regulation of prostate cancer. We utilize high-throughput genomic techniques in combination with bioinformatics/statistical analysis to generate hypothetical concepts. We then test these hypotheses using traditional molecular or cellular biological approaches and examine the functional relevance of innovative mechanisms using in vitro cell line and in vivo mouse models. Transcription factors of particular interest to us include androgen receptor (AR), FoxA1, Polycomb group protein (EZH2), and the Ets family protein (ERG). Based on the genetics and epigenetics of the disease, we also pursue translational research to define diagnostic / prognostic biomarkers and to pursue novel therapeutics strategies for treating advanced prostate cancer
Research Interest
Prostate Cancer, Cancer Biology, Genomics, Endocrinology
Publications
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Polycomb-mediated disruption of an androgen receptor feedback loop drives castration-resistant prostate cancer Fong KW, Zhao JC, Kim J, Li S, Yang YA, Song B, Rittie L, Hu M, Yang X, Perbal B, Yu J Cancer Research. 2017 Jan 15; 77(2): 412-422. doi:http://dx.doi.org/10.1158/0008-5472.CAN-16-1949. PMID: 27815387 PMCID: 27815387 ISSN: 0008-5472
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CD95/Fas Increases Stemness in Cancer Cells by Inducing a STAT1-Dependent Type I Interferon Response Qadir AS, Ceppi P, Brockway S, Law C, Mu L, Khodarev NN, Kim J, Zhao JC, Putzbach W, Murmann AE, Chen Z, Chen W, Liu X, Salomon AR, Liu H, Weichselbaum RR, Yu J, Peter ME Cell Reports. 2017 Mar 7; 18(10): 2373-2386. doi:http://dx.doi.org/10.1016/j.celrep.2017.02.037. PMID: 28273453 PMCID: 28273453 ISSN: 2211-1247
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FOXA1 inhibits prostate cancer neuroendocrine differentiation Kim J, Jin H, Zhao JC, Yang YA, Li Y, Yang X, Dong X, Yu J Oncogene. 2017 Mar 20; doi:http://dx.doi.org/10.1038/onc.2017.50. PMID: 28319070 PMCID: 28319070 ISSN: 0950-9232