Navdeep S Chandel
Professor of Medicine (Pulmonary and Critical Care
Department of Cell & Molecular Biology
Northwestern University Feinberg School of Medicine
United States of America
Biography
Historically, reactive oxygen species (ROS) have been thought to be cellular damaging agents, lacking a physiological function. Accumulation of ROS and oxidative damage have been linked to multiple pathologies, including neurodegenerative diseases, diabetes, cancer, and premature aging. This guilt by association relationship left a picture of ROS as a necessary evil of oxidative metabolism, a product of an imperfect system. Yet few biological systems possess such flagrant imperfections, thanks to the persistent optimization of evolution, and it appears that oxidative metabolism is no different. More and more evidence suggests that low levels of ROS are critical for healthy cellular function. We are testing whether mitochondrial release of H2O2 has evolved as a method of communication between mitochondrial function and other cellular processes to maintain homeostasis (e.g. stem cell function and immune responses) and promote adaptation to stress (e.g. hypoxia).
Research Interest
Lung Cancer / Chest Cancer, Immune System
Publications
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The mitochondrial respiratory chain is essential for haematopoietic stem cell function Ansó E, Weinberg SE, Diebold LP, Thompson BJ, Malinge S, Schumacker PT, Liu X, Zhang Y, Shao Z, Steadman M, Marsh KM, Xu J, Crispino JD, Chandel NS Nature Cell Biology. 2017 May 31; 19(6): 614-625. doi:http://dx.doi.org/10.1038/ncb3529. PMID: 28504706 PMCID: 28504706 ISSN: 1465-7392
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Regulation of mitochondrial biogenesis in erythropoiesis by mTORC1-mediated protein translation Liu X, Zhang Y, Ni M, Cao H, Signer RA, Li D, Li M, Gu Z, Hu Z, Dickerson KE, Weinberg SE, Chandel NS, Deberardinis RJ, Zhou F, Shao Z, Xu J Nature Cell Biology. 2017 May 31; 19(6): 626-638. doi:http://dx.doi.org/10.1038/ncb3527. PMID: 28504707 ISSN: 1465-7392
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Metabolism and skeletal muscle homeostasis in lung disease Ceco E, Weinberg SE, Chandel NS, Sznajder JI American Journal of Respiratory Cell and Molecular Biology. 2017 Jul; 57(1): 28-34. doi:http://dx.doi.org/10.1165/rcmb.2016-0355TR. PMID: 28085493 ISSN: 1044-1549
