Panagiotis Ntziachristos
Assistant Professor of Biochemistry and Molecular
Department of Biochemistry and Molecular Genetics
Northwestern University Feinberg School of Medicine
United States of America
Biography
The Ntziachristos laboratory studies the mechanistic aspects of oncogenesis with an emphasis on transcriptional and epigenetic regulation of acute leukemia. Up to 25% of children with Acute Lymphoblastic Leukemia will fail frontline therapy and their prognosis is dismal. Cure rates for patients relapsing on therapy are approximate 20%. While patients with later relapses have a better prognosis, the majority eventually succumbs to the disease (overall cure rate 40 to 50%). Important questions in our laboratory are related to how oncogenes interact with each other and with epigenetic modulators to influence gene expression programs as well as how their function is related to tri- dimensional (3D) structure of the nucleus and other biological aspects of cancer cells, like metabolism. To address these questions we use high-throughput molecular and cell biology techniques like ChIP-Seq, RNA-Seq, 4C-Seq and HiC, fluorescent in situ hybridization, biochemical analysis e.t.c. in cell lines and primary cells of human origin and tissues of mouse models of disease. In addition to understanding cancer biology these finding help us design and test targeted therapies in preclinical models of leukemia.
Research Interest
Molecular Genetics, Chromatin
Publications
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Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a Strikoudis A, Lazaris C, Trimarchi T, Galvao Neto AL, Yang Y, Ntziachristos P, Rothbart S, Buckley S, Dolgalev I, Stadtfeld M, Strahl BD, Dynlacht BD, Tsirigos A, Aifantis I Nature Cell Biology. 2016 Oct 27; 18(11): 1127-1138. doi:http://dx.doi.org/10.1038/ncb3424. PMID: 27749823 PMCID: 27749823 ISSN: 1465-7392
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Deregulation of DUX4 and ERG in acute lymphoblastic leukemia Zhang J, McCastlain K, Yoshihara H, Xu B, Chang Y, Churchman ML, Wu G, Li Y, Wei L, Iacobucci I, Liu Y, Qu C, Wen J, Edmonson M, Payne-Turner D, Kaufmann KB, Takayanagi SI, Wienholds E, Waanders E, Ntziachristos P, Bakogianni S, Wang J, Aifantis I, Roberts KG, Ma J, Song G, Easton J, Mulder HL, Chen X, Newman S, Ma X, Rusch M, Gupta P, Boggs K, Vadodaria B, Dalton J, Liu Y, Valentine ML, Ding L, Lu C, Fulton RS, Fulton L, Tabib Y, Ochoa K, Devidas M, Pei D, Cheng C, Yang J, Evans WE, Relling MV, Pui CH, Jeha S, Harvey RC, Chen IML, Willman CL, Marcucci G, Bloomfield CD, Kohlschmidt J, Mrózek K, Paietta E, Tallman MS, Stock W, Foster MC, Racevskis J, Rowe JM, Luger S, Kornblau SM, Shurtleff SA, Raimondi SC, Mardis ER, Wilson RK, Dick JE, Hunger SP, Loh ML, Downing JR, Mullighan CG, Nature Genetics. 2016 Dec; 48(12): 1481-1489. doi:http://dx.doi.org/10.1038/ng.3691. PMID: 27776115 PMCID: 27776115 ISSN: 1061-4036
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HiC-bench: Comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking Lazaris C, Kelly S, Ntziachristos P, Aifantis I, Tsirigos A BMC Genomics. 2017 Jan 5; 18(1): doi:http://dx.doi.org/10.1186/s12864-016-3387-6. PMID: 28056762 PMCID: 28056762 ISSN: 1471-2164
