Paul T Schumacker
Professor
Department of Cell & Molecular Biology
Northwestern University Feinberg School of Medicine
United States of America
Biography
Our lab is interested in the effects of oxygen on cell metabolism, and in the molecular mechanisms underlying cellular oxygen sensing. The signaling pathways activated by hypoxia, and their regulation of transcriptional and post-translational responses in diverse cell types are also of major interest. Current studies focus on the role of mitochondrial redox signaling in the development of pulmonary hypertension. Other current studies focus on cardiomyocyte regeneration in the heart and molecul.
Research Interest
Lungs, Breathing Problems, Cell Biology, Signal Transduction
Publications
-
Sirt3 protects dopaminergic neurons from mitochondrial oxidative stress Shi H, Deng HX, Gius D, Schumacker PT, Surmeier DJ, Ma YC Human Molecular Genetics. 2017 May 15; 26(10): 1915-1926. doi:http://dx.doi.org/10.1093/hmg/ddx100. PMID: 28369333 ISSN: 0964-6906
-
The mitochondrial respiratory chain is essential for haematopoietic stem cell function Ansó E, Weinberg SE, Diebold LP, Thompson BJ, Malinge S, Schumacker PT, Liu X, Zhang Y, Shao Z, Steadman M, Marsh KM, Xu J, Crispino JD, Chandel NS Nature Cell Biology. 2017 May 31; 19(6): 614-625. doi:http://dx.doi.org/10.1038/ncb3529. PMID: 28504706 PMCID: 28504706 ISSN: 1465-7392
-
Redox signaling during hypoxia in mammalian cells Smith KA, Waypa GB, Schumacker PT Redox Biology. 2017 Oct; 13: 228-234. doi:http://dx.doi.org/10.1016/j.redox.2017.05.020. PMID: 28595160 PMCID: 28595160 ISSN: 2213-2317
