Sergey M Troyanovsky
Professor
Department of Cell & Molecular Biology
Northwestern University Feinberg School of Medicine
United States of America
Biography
Dr. Troyanovsky's research focuses on cadherin, intercellular adhesion, and signaling. Classic cadherins are critical proteins mediating cell-cell adhesion and various signaling pathways responsible for cellular proliferation, differentiation, and morphogenesis. Abnormalities in this system are causal factors in many pathologies, including cancer. The molecular mechanisms of cadherin-based adhesion, however, are largely unknown. How do cadherins establish the adhesion contact? How do they interact with the cytoskeleton? What are the signaling pathways they control? Our laboratory's work is centered around these questions. We are currently working on the following specific projects.
Research Interest
Cell Adhesion Mechanisms, Cell Biology, Cell Imaging
Publications
-
Cadherin controls nectin recruitment into adherens junctions by remodeling the actin cytoskeleton Troyanovsky RB, Indra I, Chen CS, Hong S, Troyanovsky SM Journal of Cell Science. 2015 Jan; 128(1): 140-149. doi:http://dx.doi.org/10.1242/jcs.161588. PMID: 25395582 PMCID: 25395582 ISSN: 0021-9533
-
Correction to The formation of ordered nanoclusters controls cadherin anchoring to actin and cell-cell contact fluidity [The Journal Of Cell Biology, 210, 2, (2015), 333-346] DOI: 10.1083/jcb.201410111 Strale PO, Duchesne L, Peyret G, Lorraine Montel M, Nguyen T, Png E, Tampé R, Troyanovsky S, Hénon S, Ladoux B, René-Mège M Journal of Cell Biology. 2015 Jan; 210(6): 1033. doi:http://dx.doi.org/10.1083/jcb.20141011109022015c. PMID: 26370504 PMCID: 26370504 ISSN: 0021-9525
-
E-cadherin junction formation involves an active kinetic nucleation process Biswas KH, Hartman KL, Yu CH, Harrison OJ, Song H, Smith AW, Huang WYC, Lin WC, Guo Z, Padmanabhan A, Troyanovsky SM, Dustin ML, Shapiro L, Honig B, Zaidel-Bar R, Groves JT Proceedings of the National Academy of Sciences of the United States of America. 2015 Sep; 112(35): 10932-10937. doi:http://dx.doi.org/10.1073/pnas.1513775112. PMID: 26290581 PMCID: 26290581 ISSN: 0027-8424
